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Low hand grip strength (60 years and older) (EWGSOP)

ALDH1A2 · rs2899611

Where this position leads

Condition: Hand Grip Strength

rs2899611 Condition: Hand Grip Strength Hand Grip Strength Condition rs2899611 rs2899611 ALDH1A2

What the study found

Who was studied 48,596 European ancestry cases, 207,927 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0431 lower (95% confidence interval 0.029-0.058); p = 6 × 10−9.

How common The T allele had a frequency of about 50% in the people studied.

Where it sits Chromosome 15, band 15q21.3 — in an intron of ALDH1A2.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Low hand grip strength (60 years and older) (EWGSOP) — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Low hand grip strength (60 years and older) (EWGSOP).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Low hand grip strength (60 years and older) (EWGSOP) compared to the general population.
Source
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, Luan J, Sarnowski C
and 54 more — show all
Lunetta KL, Tanaka T, Wojczynski MK, Cvejkus R, Nethander M, Ghasemi S, Yang J, Zillikens MC, Walter S, Sicinski K, Kague E, Ackert-Bicknell CL, Arking DE, Windham BG, Boerwinkle E, Grove ML, Graff M, Spira D, Demuth I, van der Velde N, de Groot LCPGM, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellström D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, Völker U, Kocher T, Teumer A, Rodriguéz-Mañas L, García FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LC
Nature communications · 2021 · PMID 33510174 · open access

Questions about rs2899611

What is rs2899611?

rs2899611 is a single position in the genome, in or near the ALDH1A2 gene. Published research associates it with low hand grip strength (60 years and older) (ewgsop). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2899611 linked to?

On MyGeneLog this position is linked to Hand Grip Strength. The research behind each link, and its sources, are set out on that condition page.

Does having rs2899611 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2899611 come from?

GWAS Catalog, Nature communications 2021, PMID:33510174. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Low hand grip strength (60 years and older) (EWGSOP) (rs2899611). MyGeneLog™. https://www.mygenelog.com/variants/rs2899611

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