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Who was studied 9,626 European ancestry cases, 685,602 European ancestry controls.
The effect
Each copy of the G allele carried 1.15 times the odds of Chronic rhinosinusitis with nasal polyposis (95% confidence interval 1.104-1.199); p = 3 × 10−11.
How common The G allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 16, band 16p12.1 — in an intron of IL4R.
What each result means
A/ANo copy of the version the research linked to Chronic rhinosinusitis with nasal polyposis. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Chronic rhinosinusitis with nasal polyposis. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Chronic rhinosinusitis with nasal polyposis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 41213931 · open access
Questions about rs2891058
What is rs2891058?
rs2891058 is a single position in the genome, in or near the IL4R gene. Published research associates it with chronic rhinosinusitis with nasal polyposis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2891058 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
Does having rs2891058 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2891058 come from?
GWAS Catalog, Nature communications 2025, PMID:41213931. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Chronic rhinosinusitis with nasal polyposis (rs2891058). MyGeneLog™. https://www.mygenelog.com/variants/rs2891058