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Cholesteryl Esters to Total Lipids in Small VLDL percentage

MAP2K2 · rs2890215

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs2890215 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs2890215 rs2890215 MAP2K2

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the T allele shifted the measure 0.03 % higher (95% confidence interval 0.03-0.03); p = 6 × 10−11.

Where it sits Chromosome 19, band 19p13.3 — in an intron of MAP2K2.

What each result means

A/A No copy of the version the research linked to Cholesteryl Esters to Total Lipids in Small VLDL percentage. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Cholesteryl Esters to Total Lipids in Small VLDL percentage. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cholesteryl Esters to Total Lipids in Small VLDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2890215

What is rs2890215?

rs2890215 is a single position in the genome, in or near the MAP2K2 gene. Published research associates it with cholesteryl esters to total lipids in small vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2890215 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs2890215 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2890215 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesteryl Esters to Total Lipids in Small VLDL percentage (rs2890215). MyGeneLog™. https://www.mygenelog.com/variants/rs2890215

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