BRCA1 · rs28897672
Where this position leads
Condition: Ovarian Cancer
Strength of the evidence
ClinVar classifies it as disease-causing (or likely), reviewed at 3 of 4 stars.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What ClinVar records
Classification
Pathogenic for Breast-ovarian cancer, familial, susceptibility to, 1, Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast neoplasm and 9 more; reviewed by expert panel (3 of 4 stars, 71 submitters), last evaluated 2015-08-10.
ClinVar record 17661 NM_007294.4(BRCA1):c.181T>G (p.Cys61Gly)
Classification
Pathogenic/Likely pathogenic for Breast-ovarian cancer, familial, susceptibility to, 1, Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome, Inherited breast cancer and ovarian cancer; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-06-11.
ClinVar record 54360 NM_007294.4(BRCA1):c.181T>C (p.Cys61Arg)
Classification
Pathogenic for Breast-ovarian cancer, familial, susceptibility to, 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2020-04-02.
ClinVar record 54359 NM_007294.4(BRCA1):c.181T>A (p.Cys61Ser)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
Source: ClinVar VCV000017661, reviewed by expert panel
rs28897672 is a single position in the genome, in or near the BRCA1 gene. Published research associates it with breast-ovarian cancer, familial, susceptibility to, 1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
ClinVar VCV000017661, reviewed by expert panel. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Breast-ovarian cancer, familial, susceptibility to, 1 (rs28897672). MyGeneLog™. https://www.mygenelog.com/variants/rs28897672