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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 357,957 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0285 higher (95% confidence interval 0.019-0.037); p = 5 × 10−10.
Where it sits Chromosome 6, band 6p22.1 — in an intron of GABBR1.
What each result means
A/ANo copy of the version the research linked to Depressed affect. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Depressed affect. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Depressed affect. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs28893517 is a single position in the genome, in or near the GABBR1 gene. Published research associates it with depressed affect. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs28893517 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28893517 come from?
GWAS Catalog, Nature genetics 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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