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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 102,635 European ancestry males, 27,736 African American or Afro-Caribbean males, 13,328 Admixed American ancestry males, 1,690 East Asian ancestry males.
The effect
Each copy of the G allele shifted the measure 0.0876 lower (95% confidence interval 0.075-0.1); p = 3 × 10−45.
Where it sits Chromosome X, band Xq23 — in an intron of RTL9.
What each result means
C/CNo copy of the version the research linked to Hypogonadism. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Hypogonadism. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Hypogonadism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40316537 · open access
Questions about rs2883091
What is rs2883091?
rs2883091 is a single position in the genome, in or near the RTL9 gene. Published research associates it with hypogonadism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2883091 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2883091 come from?
GWAS Catalog, Nature communications 2025, PMID:40316537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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