Number of decayed, missing and filled tooth surfaces or use of dentures
MC4R · rs28822480
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,976 European ancestry individuals with decayed, missing or filled tooth surface measurement, 11,816 Hispanic/Latino individuals with decayed, missing or filled tooth surface measurement, 77,714 European ancestry dentures cases, 383,317 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.021 higher (95% confidence interval 0.015-0.027); p = 7 × 10−13.
How common The A allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 18, band 18q21.32 — between genes, 93.9 kb from RNU4-17P.
What each result means
A/ATwo copies of the version the research linked to Number of decayed, missing and filled tooth surfaces or use of dentures. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Number of decayed, missing and filled tooth surfaces or use of dentures. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Number of decayed, missing and filled tooth surfaces or use of dentures. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31235808 · open access
Questions about rs28822480
What is rs28822480?
rs28822480 is a single position in the genome, in or near the MC4R gene. Published research associates it with number of decayed, missing and filled tooth surfaces or use of dentures. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs28822480 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28822480 come from?
GWAS Catalog, Nature communications 2019, PMID:31235808. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Number of decayed, missing and filled tooth surfaces or use of dentures (rs28822480). MyGeneLog™. https://www.mygenelog.com/variants/rs28822480