Who was studied 133,492 European ancestry individuals.
The effect
The reported allele is A; the catalogue records no effect size
; p = 2 × 10−15.
How common The A allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 8, band 8q23.1 — between genes, 54 kb from ABRA.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intraocular pressure compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intraocular pressure.
G/GPublished research associates this genotype with typical/baseline likelihood of Intraocular pressure — no copies of the reported risk allele.
rs2881425 is a single position in the genome, in or near the ABRA gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2881425 linked to?
On MyGeneLog this position is linked to Intraocular Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs2881425 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2881425 come from?
GWAS Catalog, Nature genetics 2020, PMID:31959993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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