POU5F1B · rs28774977
Where this position leads
Condition: Colorectal Cancer
What the study found
Who was studied 15,714 European ancestry cases, 621,182 European ancestry controls, 7,062 East Asian ancestry cases, 195,745 East Asian ancestry controls.
The effect Each copy of the A allele shifted the measure 0.102 higher; p = 2 × 10−20.
Where it sits Chromosome 8, band 8q24.21 — in the 3′ untranslated region of POU5F1B.
rs28774977 is a single position in the genome, in or near the POU5F1B gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genome medicine 2024, PMID:38872215. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Colorectal cancer (rs28774977). MyGeneLog™. https://www.mygenelog.com/variants/rs28774977