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Cerebrospinal fluid protein CD8A levels

near HLA-DQB1 · rs28746898

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,524 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.447 higher (95% confidence interval 0.33-0.57); p = 3 × 10⁻¹³.

How common The G allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 12.4 kb from HLA-DQB1.

What each result means

A/A No copy of the version the research linked to Cerebrospinal fluid protein CD8A levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Cerebrospinal fluid protein CD8A levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Cerebrospinal fluid protein CD8A levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I

and 12 more — show all

Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C

Science translational medicine · 2026 · PMID 42054495

Questions about rs28746898

What is rs28746898?

rs28746898 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with cerebrospinal fluid protein cd8a levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28746898 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28746898 come from?

GWAS Catalog, Science translational medicine 2026, PMID:42054495. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid protein CD8A levels (rs28746898). MyGeneLog™. https://www.mygenelog.com/variants/rs28746898

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