Binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations)
near HLA-DQB1 · rs28746882
0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied up to 2,000 German and Swedish ancestry individuals; replicated in up to 757 German and Swedish ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.277 higher (95% confidence interval 0.19-0.36); p = 5 × 10−11.
How common The A allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 2 kb from HLA-DQB1.
What each result means
A/ATwo copies of the version the research linked to Binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations). This is the starting point the study compared everyone against.
rs28746882 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28746882 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs28746882 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28746882 come from?
GWAS Catalog, BMC medicine 2020, PMID:33143745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Binding antibody response to interferon beta therapy in multiple sclerosis (antibody levels; all treatment preparations) (rs28746882). MyGeneLog™. https://www.mygenelog.com/variants/rs28746882