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Who was studied 4,572 European ancestry cases, 266,358 European ancestry controls; replicated in up to 956 European ancestry cases, up to 4,214 European ancestry controls, 526 cases, 528 controls.
The effect
Each copy of the C allele carried 1.43 times the odds of Basal cell carcinoma (95% confidence interval 1.30-1.59); p = 4 × 10−12.
How common The C allele had a frequency of about 94% in the people studied.
Where it sits Chromosome 8, band 8q21.13 — in an intron of LOC107986952.
What each result means
C/CTwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2015 · PMID 25855136 · open access
Questions about rs28727938
What is rs28727938?
rs28727938 is a single position in the genome, in or near the ZFHX4 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28727938 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs28727938 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28727938 come from?
GWAS Catalog, Nat Commun 2015, PMID:25855136. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 392319124215Reads by AI crawlersClaude0ChatGPT2Google · Gemini3Perplexity1Meta AI9Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others15Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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