Gene Knowledge Graph
UTC
Standard

Human milk oligosaccharide concentration (difucosyllacto-N-tetrose)

NRTN · rs28721898

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 764 European ancestry individuals, 48 South Asian ancestry individuals, 126 East Asian ancestry individuals, 26 African American or Afro-Caribbean individuals, 16 Other admixed ancestry and unknown ancestry individuals; replicated in 395 individuals.

The effect Each copy of the T allele shifted the measure 10.6 zscore lower; p = 4 × 10−26.

Where it sits Chromosome 19, band 19p13.3 — in an intron of NRTN.

What each result means

C/C No copy of the version the research linked to Human milk oligosaccharide concentration (difucosyllacto-N-tetrose). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Human milk oligosaccharide concentration (difucosyllacto-N-tetrose). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Human milk oligosaccharide concentration (difucosyllacto-N-tetrose). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children
Ambalavanan A, Chang L, Choi J, Zhang Y, Stickley SA, Fang ZY, Miliku K, Robertson B, Yonemitsu C, Turvey SE, Mandhane PJ, Simons E
and 26 more — show all
Moraes TJ, Anand SS, Paré G, Williams JE, Murdoch BM, Otoo GE, Mbugua S, Kamau-Mbuthia EW, Kamundia EW, Gindola DK, Rodriguez JM, Pareja RG, Sellen DW, Moore SE, Prentice AM, Foster JA, Kvist LJ, Neibergs HL, McGuire MA, McGuire MK, Meehan CL, Sears MR, Subbarao P, Azad MB, Bode L, Duan Q
Nature communications · 2024 · PMID 39232002 · open access

Questions about rs28721898

What is rs28721898?

rs28721898 is a single position in the genome, in or near the NRTN gene. Published research associates it with human milk oligosaccharide concentration (difucosyllacto-n-tetrose). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28721898 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28721898 come from?

GWAS Catalog, Nature communications 2024, PMID:39232002. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Human milk oligosaccharide concentration (difucosyllacto-N-tetrose) (rs28721898). MyGeneLog™. https://www.mygenelog.com/variants/rs28721898

← See all variants