Gene Knowledge Graph
UTC
Standard

Basophil percentage of granulocytes

SLC45A3 · rs28721375

Where this position leads

Condition: Blood Cell Counts

rs28721375 Condition: Blood Cell Counts Blood Cell Counts Condition rs28721375 rs28721375 SLC45A3

What the study found

Who was studied 170,223 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0249 higher (95% confidence interval 0.017-0.033); p = 2 × 10−10.

How common The C allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — in a non-coding transcript of Metazoa_SRP.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Basophil percentage of granulocytes compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Basophil percentage of granulocytes.
T/T Published research associates this genotype with typical/baseline likelihood of Basophil percentage of granulocytes — no copies of the reported risk allele.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs28721375

What is rs28721375?

rs28721375 is a single position in the genome, in or near the SLC45A3 gene. Published research associates it with basophil percentage of granulocytes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28721375 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs28721375 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28721375 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Basophil percentage of granulocytes (rs28721375). MyGeneLog™. https://www.mygenelog.com/variants/rs28721375

← See all variants