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Blood glucose levels

SLC2A2 · rs28720688

Where this position leads

Condition: Gout

Drug: Metformin

rs28720688 Condition: Gout Gout Condition Drug: Metformin Metformin Drug rs28720688 rs28720688 SLC2A2

What the study found

Who was studied 313,125 European ancestry individuals, 5,568 African ancestry individuals, 6,693 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0418 lower (95% confidence interval 0.035-0.048); p = 6 × 10−35.

Where it sits Chromosome 3, band 3q26.2 — in an intron of SLC2A2.

What each result means

A/A No copy of the version the research linked to Blood glucose levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Blood glucose levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Blood glucose levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs28720688

What is rs28720688?

rs28720688 is a single position in the genome, in or near the SLC2A2 gene. Published research associates it with blood glucose levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28720688 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does rs28720688 affect how medicines work?

SLC2A2 carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs28720688 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28720688 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Blood glucose levels (rs28720688). MyGeneLog™. https://www.mygenelog.com/variants/rs28720688

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