0 33217122117Reads by AI crawlersClaude0ChatGPT0Google · Gemini2Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 18,719 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,441,938 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the C allele shifted the measure 0.0772 higher (95% confidence interval 0.05-0.105); p = 4 × 10−8.
How common The C allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 15, band 15q21.3 — in an intron of ZNF280D.
What each result means
A/ANo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs28678122
What is rs28678122?
rs28678122 is a single position in the genome, in or near the ZNF280D gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28678122 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs28678122 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28678122 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 33217122117Reads by AI crawlersClaude0ChatGPT0Google · Gemini2Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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