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Who was studied 41,917 European ancestry bipolar disorder cases, 12,194 European ancestry Crohn's disease cases, 399,621 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.016 lower (95% confidence interval 0.01-0.022); p = 5 × 10−11.
Where it sits Chromosome 8, band 8p23.1 — in an intron of MSRA.
What each result means
A/ANo copy of the version the research linked to Bipolar disorder or Crohn's disease (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Bipolar disorder or Crohn's disease (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Bipolar disorder or Crohn's disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of affective disorders · 2024 · PMID 38154582
Questions about rs28653100
What is rs28653100?
rs28653100 is a single position in the genome, in or near the MSRA gene. Published research associates it with bipolar disorder or crohn's disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28653100 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs28653100 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28653100 come from?
GWAS Catalog, Journal of affective disorders 2024, PMID:38154582. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Bipolar disorder or Crohn's disease (MTAG) (rs28653100). MyGeneLog™. https://www.mygenelog.com/variants/rs28653100