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Who was studied 15,225 European ancestry cases, 1,564,786 European ancestry controls, 2,551 East Asian ancestry cases, 176,175 East Asian ancestry controls, 224 African American cases, 21,969 African American controls, 265 Hispanic cases, 19,117 Hispanic controls; replicated in 14,041 European ancestry cases, 445,656 European ancestry controls, 4,948 African American cases, 118,739 African American controls, 2,700 Hispanic cases, 55,334 Hispanic controls.
The effect
Each copy of the T allele shifted the measure 0.142 lower (95% confidence interval 0.12-0.17); p = 2 × 10−29.
Where it sits Chromosome 4, band 4q22.1 — in an intron of HSD17B13.
What each result means
C/CNo copy of the version the research linked to Cirrhosis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Cirrhosis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cirrhosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2024 · PMID 38632349 · open access
Questions about rs28636836
What is rs28636836?
rs28636836 is a single position in the genome, in or near the HSD17B13 gene. Published research associates it with cirrhosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28636836 linked to?
On MyGeneLog this position is linked to Alcohol-Related Cirrhosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs28636836 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28636836 come from?
GWAS Catalog, Nature genetics 2024, PMID:38632349. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 1028Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others8Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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