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LDL cholesterol levels

TOMM20 · rs28631087

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 440,546 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0162 higher (95% confidence interval 0.011-0.021); p = 2 × 10⁻¹⁰.

How common The T allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 1, band 1q42.3 — between genes, 3.4 kb from LNCATV.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of LDL cholesterol levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LDL cholesterol levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LDL cholesterol levels compared to the general population.

Source

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV

PLoS medicine · 2020 · PMID 32203549 · open access

Questions about rs28631087

What is rs28631087?

rs28631087 is a single position in the genome, in or near the TOMM20 gene. Published research associates it with ldl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28631087 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28631087 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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LDL cholesterol levels (rs28631087). MyGeneLog™. https://www.mygenelog.com/variants/rs28631087

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