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Asthma

near HLA-DQB1 · rs28629976

Where this position leads

Condition: Asthma

rs28629976 Condition: Asthma Asthma Condition rs28629976 rs28629976 near HLA-DQB1

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.12 lower (95% confidence interval 0.083-0.156); p = 9 × 10−12.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 2 kb from HLA-DQB1.

What each result means

C/C Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source

Questions about rs28629976

What is rs28629976?

rs28629976 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28629976 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs28629976 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28629976 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs28629976). MyGeneLog™. https://www.mygenelog.com/variants/rs28629976

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