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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−12, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 321,047 European ancestry individuals; replicated in 79,005 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0168 higher (95% confidence interval 0.012-0.021); p = 9 × 10−13.
How common The C allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 1, band 1q41 — between genes, 139.8 kb from U3.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of FEV1 compared to the general population.
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with FEV1.
G/GPublished research associates this genotype with typical/baseline likelihood of FEV1 — no copies of the reported risk allele.
Nature genetics · 2019 · PMID 30804560 · open access
Questions about rs28613267
What is rs28613267?
rs28613267 is a single position in the genome, in or near the MIR548F3/TGFB2 gene. Published research associates it with fev1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs28613267 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28613267 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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