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Neuroticism

TCF4 · rs28602385

Where this position leads

Condition: Neuroticism

rs28602385 Condition: Neuroticism Neuroticism Condition rs28602385 rs28602385 TCF4

What the study found

Who was studied 449,484 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 6.28 z score higher (95% confidence interval -); p = 3 × 10−10.

Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.

What each result means

A/A Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/G No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
Source

Questions about rs28602385

What is rs28602385?

rs28602385 is a single position in the genome, in or near the TCF4 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28602385 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs28602385 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28602385 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs28602385). MyGeneLog™. https://www.mygenelog.com/variants/rs28602385

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