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Pediatric steroid sensitive nephrotic syndrome

NFKBIL1 · rs2857607

Where this position leads

Condition: Childhood Steroid-Sensitive Nephrotic Syndrome

rs2857607 Condition: Childhood Steroid-Sensitive Nephrotic Syndrome Childhood Steroid-Sensitive Nephrot… Condition rs2857607 rs2857607 NFKBIL1

What the study found

Who was studied 1,096 European ancestry cases, 12,459 European ancestry controls.

The effect Each copy of the T allele carried 1.95 times the odds of Pediatric steroid sensitive nephrotic syndrome (95% confidence interval 1.66-2.31); p = 1 × 10−13.

Where it sits Chromosome 6, band 6p21.33 — in an intron of NFKBIL1.

What each result means

C/C No copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Barry A, McNulty MT, Jia X, Gupta Y, Debiec H, Luo Y, Nagano C, Horinouchi T, Jung S, Colucci M, Ahram DF, Mitrotti A
and 58 more — show all
Sinha A, Teeninga N, Jin G, Shril S, Caridi G, Bodria M, Lim TY, Westland R, Zanoni F, Marasa M, Turudic D, Giordano M, Gesualdo L, Magistroni R, Pisani I, Fiaccadori E, Reiterova J, Maringhini S, Morello W, Montini G, Weng PL, Scolari F, Saraga M, Tasic V, Santoro D, van Wijk JAE, Milošević D, Kawai Y, Kiryluk K, Pollak MR, Gharavi A, Lin F, Simœs E Silva AC, Loos RJF, Kenny EE, Schreuder MF, Zurowska A, Dossier C, Ariceta G, Drozynska-Duklas M, Hogan J, Jankauskiene A, Hildebrandt F, Prikhodina L, Song K, Bagga A, Cheong H 2nd, Ghiggeri GM, Vachvanichsanong P, Nozu K, Lee D, Vivarelli M, Raychaudhuri S, Tokunaga K, Sanna-Cherchi S, Ronco P, Iijima K, Sampson MG
Nature communications · 2023 · PMID 37120605 · open access

Questions about rs2857607

What is rs2857607?

rs2857607 is a single position in the genome, in or near the NFKBIL1 gene. Published research associates it with pediatric steroid sensitive nephrotic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2857607 linked to?

On MyGeneLog this position is linked to Childhood Steroid-Sensitive Nephrotic Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs2857607 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2857607 come from?

GWAS Catalog, Nature communications 2023, PMID:37120605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pediatric steroid sensitive nephrotic syndrome (rs2857607). MyGeneLog™. https://www.mygenelog.com/variants/rs2857607

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