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Thrombin generation potential phenotypes

MYBPC3 · rs2856656

Where this position leads

Condition: Fibrinogen and Blood Clotting

rs2856656 Condition: Fibrinogen and Blood Clotting Fibrinogen and Blood Clotting Condition rs2856656 rs2856656 MYBPC3

What the study found

Who was studied 714 European ancestry venous thrombosis cases, 1,253 European ancestry individuals; replicated in 714 European ancestry venous thrombosis cases, 543 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.189 nM/min higher (95% confidence interval 0.15-0.23); p = 5 × 10−22.

Where it sits Chromosome 11, band 11p11.2 — in an intron of MYBPC3.

What each result means

C/C Two copies of the version the research linked to Thrombin generation potential phenotypes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Thrombin generation potential phenotypes. That is a smaller link than two copies.
T/T No copy of the version the research linked to Thrombin generation potential phenotypes. This is the starting point the study compared everyone against.
Source

Questions about rs2856656

What is rs2856656?

rs2856656 is a single position in the genome, in or near the MYBPC3 gene. Published research associates it with thrombin generation potential phenotypes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2856656 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

Does having rs2856656 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2856656 come from?

GWAS Catalog, Blood 2013, PMID:24357727. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thrombin generation potential phenotypes (rs2856656). MyGeneLog™. https://www.mygenelog.com/variants/rs2856656

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