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Sensitive

Lung adenocarcinoma

CDKN2B-AS1 · rs28557075

Where this position leads

Condition: EGFR Mutation-Positive Lung Adenocarcinoma

rs28557075 Condition: EGFR Mutation-Positive Lung Adenocarcinoma EGFR Mutation-Positive Lung Adenoca… Condition rs28557075 rs28557075 CDKN2B-AS1

What the study found

Who was studied 13,292 European ancestry cases, 67,596 European ancestry controls; replicated in 7,042 European ancestry cases, 13,599 European ancestry controls.

The effect Each copy of the A allele carried 1.18 times the odds of Lung adenocarcinoma (95% confidence interval 1.128-1.235); p = 1 × 10−12.

How common The A allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung adenocarcinoma compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung adenocarcinoma.
G/G Published research associates this genotype with typical/baseline likelihood of Lung adenocarcinoma — no copies of the reported risk allele.
Source
Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk
Gorman BR, Ji SG, Francis M, Sendamarai AK, Shi Y, Devineni P, Saxena U, Partan E, DeVito AK, Byun J, Han Y, Xiao X
and 11 more — show all
Sin DD, Timens W, Moser J, Muralidhar S, Ramoni R, Hung RJ, McKay JD, Bossé Y, Sun R, Amos CI, Pyarajan S
VA Million Veteran Program
Nature communications · 2024 · PMID 39366959 · open access

Questions about rs28557075

What is rs28557075?

rs28557075 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28557075 linked to?

On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs28557075 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28557075 come from?

GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung adenocarcinoma (rs28557075). MyGeneLog™. https://www.mygenelog.com/variants/rs28557075

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