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Familial combined hyperlipidemia defined by Brunzell criteria

near LINC-PINT · rs28544889

What the study found

Who was studied 3,838 British ancestry cases, 345,384 British ancestry controls.

The effect Each copy of the C allele shifted the measure 0.154 lower (95% confidence interval 0.11-0.2); p = 2 × 10−10.

How common The C allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 7, band 7q32.2 — between genes, 15.7 kb from LINC-PINT.

What each result means

A/A No copy of the version the research linked to Familial combined hyperlipidemia defined by Brunzell criteria. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Familial combined hyperlipidemia defined by Brunzell criteria. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Familial combined hyperlipidemia defined by Brunzell criteria. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs28544889

What is rs28544889?

rs28544889 is a single position in the genome, in or near the near LINC-PINT gene. Published research associates it with familial combined hyperlipidemia defined by brunzell criteria. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28544889 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28544889 come from?

GWAS Catalog, Atherosclerosis 2022, PMID:34906840. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Familial combined hyperlipidemia defined by Brunzell criteria (rs28544889). MyGeneLog™. https://www.mygenelog.com/variants/rs28544889

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