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Who was studied 234,802 European ancestry individuals; replicated in 100,556 European ancestry individuals.
The effect
The reported allele is G; the catalogue records no effect size
; p = 4 × 10−80.
How common The G allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 10.4 kb from HLA-B.
What each result means
A/ANo copy of the version the research linked to Neutrophil count. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Neutrophil count. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Neutrophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
American journal of human genetics · 2021 · PMID 34469753
Questions about rs2854011
What is rs2854011?
rs2854011 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with neutrophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2854011 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs2854011 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2854011 come from?
GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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