1 1722328Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,391 European ancestry early-onset cases, 22,407 European ancestry controls; replicated in 871 early-onset cases, 109,843 controls.
The effect
Each copy of the T allele carried 0.39 times the odds of Early-onset myasthenia gravis (95% confidence interval 0.3-0.48); p = 3 × 10−91.
How common The T allele had a frequency of about 91% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 0.8 kb from RNU6-283P.
What each result means
C/CNo copy of the version the research linked to Early-onset myasthenia gravis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Early-onset myasthenia gravis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Early-onset myasthenia gravis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39537604 · open access
Questions about rs2853986
What is rs2853986?
rs2853986 is a single position in the genome, in or near the near RNU6-283P gene. Published research associates it with early-onset myasthenia gravis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2853986 linked to?
On MyGeneLog this position is linked to Myasthenia Gravis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2853986 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2853986 come from?
GWAS Catalog, Nature communications 2024, PMID:39537604. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 1722328Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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