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Who was studied 2,514 Chinese ancestry cases, 1,130 Chinese ancestry controls; replicated in 6,600 Chinese ancestry cases, 8,127 Chinese ancestry controls.
The effect
Each copy of the A allele carried 1.47 times the odds of Chronic hepatitis B infection (95% confidence interval 1.35-1.59); p = 5 × 10−20.
How common The A allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 1 kb from HLA-C.
What each result means
A/ATwo copies of the version the research linked to Chronic hepatitis B infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Chronic hepatitis B infection. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Chronic hepatitis B infection. This is the starting point the study compared everyone against.
rs2853953 is a single position in the genome, in or near the HLA-C gene. Published research associates it with chronic hepatitis b infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2853953 linked to?
On MyGeneLog this position is linked to Chronic Hepatitis B. The research behind each link, and its sources, are set out on that condition page.
Does having rs2853953 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2853953 come from?
GWAS Catalog, Hepatology (Baltimore, Md.) 2015, PMID:25802187. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 162212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others12Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Chronic hepatitis B infection (rs2853953). MyGeneLog™. https://www.mygenelog.com/variants/rs2853953