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Type 2 lactosamine alpha-2,3-sialyltransferase levels

ST3GAL6 · rs28489284

What the study found

Who was studied 3,506 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 1.74 lower (95% confidence interval 1.64-1.83); p = 2 × 10−240.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 3, band 3q12.1 — a missense change in ST3GAL6.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 lactosamine alpha-2,3-sialyltransferase levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 lactosamine alpha-2,3-sialyltransferase levels.
G/G Published research associates this genotype with typical/baseline likelihood of Type 2 lactosamine alpha-2,3-sialyltransferase levels — no copies of the reported risk allele.
Source

Questions about rs28489284

What is rs28489284?

rs28489284 is a single position in the genome, in or near the ST3GAL6 gene. Published research associates it with type 2 lactosamine alpha-2,3-sialyltransferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28489284 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28489284 come from?

GWAS Catalog, Nature genetics 2024, PMID:39528825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Type 2 lactosamine alpha-2,3-sialyltransferase levels (rs28489284). MyGeneLog™. https://www.mygenelog.com/variants/rs28489284

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