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Who was studied 405,540 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.00908 lower (95% confidence interval 0.006-0.0121); p = 5 × 10−9.
How common The T allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 17, band 17q25.1 — in an intron of GRB2.
What each result means
C/CNo copy of the version the research linked to Height (baseline). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Height (baseline). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Height (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40374629 · open access
Questions about rs28488378
What is rs28488378?
rs28488378 is a single position in the genome, in or near the GRB2 gene. Published research associates it with height (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28488378 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs28488378 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28488378 come from?
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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