Sensitive

Schizophrenia

RNF111 · rs28473013

Where this position leads

Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)

rs28473013 Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk) Autism Spectrum Disorder and Schizo… Condition rs28473013 rs28473013 RNF111

What the study found

Who was studied 11,361 European ancestry female cases, 18,119 European ancestry female controls, 20,206 European ancestry male cases, 19,375 European ancestry male controls.

The effect Each copy of the T allele shifted the measure 0.115 lower (95% confidence interval 0.075-0.154); p = 1 × 10−8.

How common The T allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 15, band 15q22.1 — in an intron of RNF111.

What each result means

C/C No copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs28473013

What is rs28473013?

rs28473013 is a single position in the genome, in or near the RNF111 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28473013 linked to?

On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.

Does having rs28473013 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28473013 come from?

GWAS Catalog, Biological psychiatry 2022, PMID:34099189. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs28473013). MyGeneLog™. https://www.mygenelog.com/variants/rs28473013

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