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Who was studied 725 European ancestry cases, 11,145 European ancestry controls; replicated in 363 European ancestry cases.
The effect
The reported allele is T; the catalogue records no effect size
; p = 2 × 10−8.
Where it sits Chromosome 8, band 8q22.3 — inside ZFPM2.
What each result means
C/CNo copy of the version the research linked to Glaucoma (low intraocular pressure). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Glaucoma (low intraocular pressure). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (low intraocular pressure). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2016 · PMID 26752265 · open access
Questions about rs284491
What is rs284491?
rs284491 is a single position in the genome, in or near the ZFPM2 gene. Published research associates it with glaucoma (low intraocular pressure). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs284491 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs284491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs284491 come from?
GWAS Catalog, Nature genetics 2016, PMID:26752265. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 413Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others3Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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