Sensitive

Type 2 diabetes

POU5F1 · rs2844623

Where this position leads

Condition: Type 2 Diabetes

rs2844623 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs2844623 rs2844623 POU5F1

What the study found

Who was studied 36,614 Japanese ancestry cases, 155,150 Japanese ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 1 × 10−17.

How common The C allele had a frequency of about 78% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 4 kb from HLA-C.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/T No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Source

Questions about rs2844623

What is rs2844623?

rs2844623 is a single position in the genome, in or near the POU5F1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2844623 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs2844623 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2844623 come from?

GWAS Catalog, Nature genetics 2019, PMID:30718926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs2844623). MyGeneLog™. https://www.mygenelog.com/variants/rs2844623

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