Standard
Dentate gyrus molecular layer volume
FAM53B · rs28411166
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 21,297 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 7.32 mm3 higher; p = 2 × 10−10.
Where it sits Chromosome 10, band 10q26.13 — between genes, 3.8 kb from NPM1P31.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Dentate gyrus molecular layer volume — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Dentate gyrus molecular layer volume.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Dentate gyrus molecular layer volume compared to the general population.
Source
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
van der Meer D,
Rokicki J,
Kaufmann T,
Córdova-Palomera A,
Moberget T,
Alnæs D,
Bettella F,
Frei O,
Doan NT,
Sønderby IE,
Smeland OB,
Agartz I
and 42 more — show all
Bertolino A,
Bralten J,
Brandt CL,
Buitelaar JK,
Djurovic S,
van Donkelaar M,
Dørum ES,
Espeseth T,
Faraone SV,
Fernández G,
Fisher SE,
Franke B,
Haatveit B,
Hartman CA,
Hoekstra PJ,
Håberg AK,
Jönsson EG,
Kolskår KK,
Le Hellard S,
Lund MJ,
Lundervold AJ,
Lundervold A,
Melle I,
Monereo Sánchez J,
Norbom LC,
Nordvik JE,
Nyberg L,
Oosterlaan J,
Papalino M,
Papassotiropoulos A,
Pergola G,
de Quervain DJF,
Richard G,
Sanders AM,
Selvaggi P,
Shumskaya E,
Steen VM,
Tønnesen S,
Ulrichsen KM,
Zwiers MP,
Andreassen OA,
Westlye LT
Molecular psychiatry · 2020 · PMID 30279459 · open access
Questions about rs28411166
What is rs28411166?
rs28411166 is a single position in the genome, in or near the FAM53B gene. Published research associates it with dentate gyrus molecular layer volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs28411166 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28411166 come from?
GWAS Catalog, Mol Psychiatry 2018, PMID:30279459. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Dentate gyrus molecular layer volume (rs28411166). MyGeneLog™. https://www.mygenelog.com/variants/rs28411166
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