Sensitive

Systemic lupus erythematosus

MTF1 · rs28411034

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 4,222 Han Chinese ancestry cases, 8,431 Han Chinese ancestry controls, 4,576 European ancestry cases, 8,039 European ancestry controls.

The effect Each copy of the A allele carried 0.86 times the odds of Systemic lupus erythematosus (95% confidence interval 0.81-0.91); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 1, band 1p34.3 — in the 3′ untranslated region of MTF1.

How common each version is

AG

Korean KRGDB

A 32.4% · G 67.7%

Korean Korea4K

A 33.1% · G 66.9%

Japanese ToMMo

A 35.7% · G 64.3%

Vietnamese

A 20.8% · G 79.2%

World gnomAD

A 23.8% · G 76.2%

World 1000 Genomes

A 20.9% · G 79.0%

World TOPMed

A 21.3% · G 78.7%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.

G/G No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.

Source

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y

and 23 more — show all

He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W

Nature communications · 2021 · PMID 33536424 · open access

Questions about rs28411034

What is rs28411034?

rs28411034 is a single position in the genome, in or near the MTF1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28411034 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs28411034 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28411034 come from?

GWAS Catalog, Nat Commun 2021, PMID:33536424. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Systemic lupus erythematosus (rs28411034). MyGeneLog™. https://www.mygenelog.com/variants/rs28411034

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