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Who was studied 217,530 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, rheumatoid arthritis and multiple sclerosis samples).
The effect
Each copy of the A allele shifted the measure 0.02 lower (95% confidence interval 0.014-0.026); p = 3 × 10−11.
How common The A allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 12, band 12p12.3 — inside RERG.
What each result means
A/ATwo copies of the version the research linked to Endometriosis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Endometriosis (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Endometriosis (MTAG). This is the starting point the study compared everyone against.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs28410854
What is rs28410854?
rs28410854 is a single position in the genome, in or near the RERG gene. Published research associates it with endometriosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28410854 linked to?
On MyGeneLog this position is linked to Endometriosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs28410854 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28410854 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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