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Systolic blood pressure

CYP11B2 · rs28394055

Where this position leads

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0174 lower (95% confidence interval 0.014-0.021); p = 1 × 10⁻²⁸.

Where it sits Chromosome 8, band 8q24.3 — in an intron of GML.

What ClinVar records

Classification Benign for Corticosterone methyloxidase type 2 deficiency, Corticosterone 18-monooxygenase deficiency; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-07-01. ClinVar record 1177017 NM_000498.3(CYP11B2):c.396-262G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures

Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P

Nature communications · 2025 · PMID 40436827 · open access

Questions about rs28394055

What is rs28394055?

rs28394055 is a single position in the genome, in or near the CYP11B2 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28394055 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs28394055 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28394055 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systolic blood pressure (rs28394055). MyGeneLog™. https://www.mygenelog.com/variants/rs28394055

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