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Hodgkin's lymphoma

near HLA-DQA1 · rs28383311

Where this position leads

Condition: Hodgkin Lymphoma

rs28383311 Condition: Hodgkin Lymphoma Hodgkin Lymphoma Condition rs28383311 rs28383311 near HLA-DQA1

What the study found

Who was studied 1,286 European ancestry cases, 6,193 European ancestry non-Hodgkin lymphoma childhood cancer cases, 369 European ancestry non-cancer controls.

The effect Each copy of the A allele carried 1.80 times the odds of Hodgkin's lymphoma (95% confidence interval 1.59-2.03); p = 2 × 10−21.

Where it sits Chromosome 6, band 6p21.32 — between genes, 8.9 kb from HLA-DQA1.

What each result means

A/A Two copies of the version the research linked to Hodgkin's lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Hodgkin's lymphoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Hodgkin's lymphoma. This is the starting point the study compared everyone against.
Source

Questions about rs28383311

What is rs28383311?

rs28383311 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with hodgkin's lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28383311 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs28383311 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28383311 come from?

GWAS Catalog, JAMA network open 2022, PMID:35939300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hodgkin's lymphoma (rs28383311). MyGeneLog™. https://www.mygenelog.com/variants/rs28383311

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