Asparaginase hypersensitivity in acute lymphoblastic leukemia
HLA-DQA1 · rs28383308
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,290 European ancestry individuals, 310 African ancestry individuals, 798 Native American individuals, 112 Asian ancestry individuals, 387 individuals.
The effect
Each copy of the T allele carried 1.95 times the odds of Asparaginase hypersensitivity in acute lymphoblastic leukemia; p = 5 × 10−14.
Where it sits Chromosome 6, band 6p21.32 — between genes, 9.2 kb from HLA-DQA1.
What each result means
C/CNo copy of the version the research linked to Asparaginase hypersensitivity in acute lymphoblastic leukemia. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Asparaginase hypersensitivity in acute lymphoblastic leukemia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Asparaginase hypersensitivity in acute lymphoblastic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Clinical pharmacology and therapeutics · 2021 · PMID 33768542
Questions about rs28383308
What is rs28383308?
rs28383308 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with asparaginase hypersensitivity in acute lymphoblastic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28383308 linked to?
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs28383308 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28383308 come from?
GWAS Catalog, Clinical pharmacology and therapeutics 2021, PMID:33768542. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Asparaginase hypersensitivity in acute lymphoblastic leukemia (rs28383308). MyGeneLog™. https://www.mygenelog.com/variants/rs28383308