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Psoriasis vulgaris (age of onset)

near HLA-DQA1 · rs28383305

Where this position leads

Condition: Psoriasis

rs28383305 Condition: Psoriasis Psoriasis Condition rs28383305 rs28383305 near HLA-DQA1

What the study found

Who was studied 441 Japanese ancestry early-onset cases, 450 Japanese ancestry late-onset cases.

The effect Each copy of the G allele carried 2.31 times the odds of Psoriasis vulgaris (age of onset) (95% confidence interval 1.82-2.94); p = 8 × 10−12.

How common The G allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 9.2 kb from HLA-DQA1.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis vulgaris (age of onset) compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis vulgaris (age of onset).
T/T Published research associates this genotype with typical/baseline likelihood of Psoriasis vulgaris (age of onset) — no copies of the reported risk allele.
Source
Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene
Sonehara K, Watanabe R, Matsumura Y, Mitsui Y, Ogawa Y, Odomari K, Sakaue S, Namba S, Komuro M, Edamoto M, Watanabe J, Hirota T
and 59 more — show all
Arase N, Nakamura Y, Nakajima K, Okamoto T, Nishikawa R, Yamamoto K, Suzuki K, Kishikawa T, Edahiro R, Shirai Y, Naito T, Sasa N, Ishitsuka Y, Furuta J, Kunimoto K, Kajihara I, Fukushima S, Miyachi H, Matsue H, Kamata M, Momose M, Miyagawa I, Tanaka H, Ueno M, Bito T, Nagai H, Ikeda T, Horikawa T, Adachi A, Matsubara T, Nishida E, Matsuda K, Shojima N, Nakagawa I, Asano Y, Sato S, Imafuku S, Tada Y, Nishigori C, Jinnin M, Ihn H, Asahina A, Saeki H, Yamauchi T, Kadowaki T, Kawamura T, Shimada S, Katayama I, Higasa K, Noguchi E, Sano S, Tanaka Y, Matsuda F, Kumanogoh A, Tamari M, Satoh T, Fujimoto M, Morita A, Okada Y
Biobank Japan Project
Cell genomics · 2025 · PMID 40848718 · open access

Questions about rs28383305

What is rs28383305?

rs28383305 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with psoriasis vulgaris (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28383305 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs28383305 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28383305 come from?

GWAS Catalog, Cell genomics 2025, PMID:40848718. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis vulgaris (age of onset) (rs28383305). MyGeneLog™. https://www.mygenelog.com/variants/rs28383305

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