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Who was studied 983 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.15 higher; p = 9 × 10−11.
How common The G allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of LNCOB1.
What each result means
A/ANo copy of the version the research linked to Cerebral amyloid deposition (PET imaging). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Cerebral amyloid deposition (PET imaging). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Cerebral amyloid deposition (PET imaging). That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2021 · PMID 30361487 · open access
Questions about rs283815
What is rs283815?
rs283815 is a single position in the genome, in or near the PVRL2 gene. Published research associates it with cerebral amyloid deposition (pet imaging). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs283815 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does having rs283815 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs283815 come from?
GWAS Catalog, Mol Psychiatry 2018, PMID:30361487. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 373234122218Reads by AI crawlersClaude0ChatGPT3Google · Gemini2Perplexity3Meta AI4Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others18Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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