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Pneumonia

near HLA-B · rs28380929

Where this position leads

Condition: Colon Polyp

rs28380929 Condition: Colon Polyp Colon Polyp Condition rs28380929 rs28380929 near HLA-B

What the study found

Who was studied 7,423 East Asian ancestry cases, 171,303 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.709 higher (95% confidence interval 0.56-0.85); p = 5 × 10−22.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 2 kb from HLA-B.

What each result means

C/C No copy of the version the research linked to Pneumonia. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pneumonia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pneumonia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs28380929

What is rs28380929?

rs28380929 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with pneumonia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28380929 linked to?

On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs28380929 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28380929 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pneumonia (rs28380929). MyGeneLog™. https://www.mygenelog.com/variants/rs28380929

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