Standard

Lung function (FVC)

near HLA-DRB1 · rs28366282

What the study found

Who was studied 100,285 Chinese ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.035 L higher (95% confidence interval 0.025-0.045); p = 3 × 10−11.

How common The C allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 2.7 kb from HLA-DRB1.

What each result means

C/C Two copies of the version the research linked to Lung function (FVC). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Lung function (FVC). That is a smaller link than two copies.
T/T No copy of the version the research linked to Lung function (FVC). This is the starting point the study compared everyone against.
Source

Questions about rs28366282

What is rs28366282?

rs28366282 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with lung function (fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs28366282 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28366282 come from?

GWAS Catalog, The European respiratory journal 2021, PMID:33766948. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung function (FVC) (rs28366282). MyGeneLog™. https://www.mygenelog.com/variants/rs28366282

← See all variants