Gene Knowledge Graph
UTC
Sensitive

Rheumatoid arthritis (ACPA-positive)

RCAN1 · rs2834512

Where this position leads

Condition: Rheumatoid Arthritis

rs2834512 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs2834512 rs2834512 RCAN1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Rheumatoid arthritis (ACPA-positive) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Rheumatoid arthritis (ACPA-positive).
G/G Published research associates this genotype with typical/baseline likelihood of Rheumatoid arthritis (ACPA-positive) — no copies of the reported risk allele.
Source
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L
and 32 more — show all
Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D, Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J
Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate · Wellcome Trust Case Control Consortium
Nature genetics · 2012 · PMID 23143596 · open access

Questions about rs2834512

What is rs2834512?

rs2834512 is a single position in the genome, in or near the RCAN1 gene. Published research associates it with rheumatoid arthritis (acpa-positive). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2834512 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2834512 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2834512 come from?

GWAS Catalog, Nat Genet 2012, PMID:23143596. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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