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Who was studied 90,653 European ancestry cases, 1,188,957 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.047 lower (95% confidence interval 0.031-0.063); p = 3 × 10−10.
Where it sits Chromosome 21, band 21q21.3 — in an intron of BACH1.
What each result means
A/ATwo copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Heart failure. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37429843 · open access
Questions about rs2832275
What is rs2832275?
rs2832275 is a single position in the genome, in or near the BACH1 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2832275 linked to?
On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.
Does having rs2832275 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2832275 come from?
GWAS Catalog, Nature communications 2023, PMID:37429843. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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