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Who was studied 52,107 European ancestry individuals; replicated in 48,997 individuals.
The effect
Each copy of the A allele shifted the measure 0.58 lower (95% confidence interval 0.44-0.72); p = 1 × 10−14.
How common The A allele had a frequency of about 60% in the people studied.
Where it sits Chromosome 21, band 21q21.3 — in an intron of LINC00189.
What each result means
A/ATwo copies of the version the research linked to QT interval. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to QT interval. That is a smaller link than two copies.
T/TNo copy of the version the research linked to QT interval. This is the starting point the study compared everyone against.
Human molecular genetics · 2021 · PMID 34274964 · open access
Questions about rs2832274
What is rs2832274?
rs2832274 is a single position in the genome, in or near the LINC00189 gene. Published research associates it with qt interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2832274 linked to?
On MyGeneLog this position is linked to QT Interval and Drug-Induced Long QT. The research behind each link, and its sources, are set out on that condition page.
Does having rs2832274 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2832274 come from?
GWAS Catalog, Human molecular genetics 2021, PMID:34274964. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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