Gene Knowledge Graph
UTC
Standard

Umbilical hernia

LYPLAL1-AS1 · rs2820449

Where this position leads

Condition: Inguinal Hernia

rs2820449 Condition: Inguinal Hernia Inguinal Hernia Condition rs2820449 rs2820449 LYPLAL1-AS1

What the study found

Who was studied 3,211 European ancestry cases, 272,335 European ancestry controls; replicated in 1,078 European ancestry cases, 90,770 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10−18.

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 1, band 1q41 — in an intron of LYPLAL1-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Umbilical hernia compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Umbilical hernia.
G/G Published research associates this genotype with typical/baseline likelihood of Umbilical hernia — no copies of the reported risk allele.
Source
Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank
Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J
Hernia : the journal of hernias and abdominal wall surgery · 2022 · PMID 34382107

Questions about rs2820449

What is rs2820449?

rs2820449 is a single position in the genome, in or near the LYPLAL1-AS1 gene. Published research associates it with umbilical hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2820449 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs2820449 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2820449 come from?

GWAS Catalog, Hernia : the journal of hernias and abdominal wall surgery 2022, PMID:34382107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Umbilical hernia (rs2820449). MyGeneLog™. https://www.mygenelog.com/variants/rs2820449

← See all variants