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Caudate iron levels (quantitative susceptibility mapping)

RUNX2 · rs2820340

What the study found

Who was studied 39,533 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0511 lower (95% confidence interval 0.037-0.065); p = 1 × 10−14.

Where it sits Chromosome 6, band 6p21.1 — in an intron of RUNX2.

What each result means

A/A No copy of the version the research linked to Caudate iron levels (quantitative susceptibility mapping). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Caudate iron levels (quantitative susceptibility mapping). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Caudate iron levels (quantitative susceptibility mapping). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2820340

What is rs2820340?

rs2820340 is a single position in the genome, in or near the RUNX2 gene. Published research associates it with caudate iron levels (quantitative susceptibility mapping). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2820340 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2820340 come from?

GWAS Catalog, Neurobiology of disease 2024, PMID:38789058. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Caudate iron levels (quantitative susceptibility mapping) (rs2820340). MyGeneLog™. https://www.mygenelog.com/variants/rs2820340

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