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Waist-to-hip ratio adjusted for BMI x sex interaction

PLXND1 · rs2811434

Where this position leads

Condition: Obesity and Body Weight

rs2811434 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs2811434 rs2811434 PLXND1

What the study found

Who was studied up to 113,720 European ancestry men, up to 138,655 European ancestry women.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10−8.

How common The T allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 3, band 3q22.1 — between genes, 5 kb from LOC124909431.

What each result means

G/G No copy of the version the research linked to Waist-to-hip ratio adjusted for BMI x sex interaction. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Waist-to-hip ratio adjusted for BMI x sex interaction. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Waist-to-hip ratio adjusted for BMI x sex interaction. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2811434

What is rs2811434?

rs2811434 is a single position in the genome, in or near the PLXND1 gene. Published research associates it with waist-to-hip ratio adjusted for bmi x sex interaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2811434 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs2811434 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2811434 come from?

GWAS Catalog, PLoS Genet 2015, PMID:26426971. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Waist-to-hip ratio adjusted for BMI x sex interaction (rs2811434). MyGeneLog™. https://www.mygenelog.com/variants/rs2811434

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